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LALGUARD AZA is a water-soluble, botanical insecticide applied by microinjection
into the active sapwood of affected trees. The active ingredient, azadirachtin,
is derived from the neem tree, and is an extract of neem seeds (not neem oil). It is
not a neonicotinoid (i.e.: imidacloprid) or from the avermectin family of pesticides
(i.e.: emamectin benzoate).


  • Compatible with multiple tree injection systems, in addition to the EcoJect
  • No known risk of resistance due to multiple modes of action, making it a key
    tool in IPM programs.
  • Translocates rapidly (within 48 hours) throughout the tree, providing
    protection immediately post-injection.
  • Degrades naturally within tree and leaf tissues, and does not persist in soil
    and aquatic environments.
  • Formulated with a naturally occurring active ingredient that poses minimal
    risk to applicators, bystanders, bees, other pollinators, pets and wildlife.

Related Pest & Pathogens

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Safety Data Sheet
  • LALGUARD AZA is a water soluble biopesticide that is injected directly into the base of trees or used as a foliar or bark spray to manage forest insect pests.
  • When injected, LALGUARD AZA provides up to two (2) years protection against emerald ash borer.
  • The active ingredient in LALGUARD AZA is azadirachtin (6% formulation).
  • LALGUARD AZA’s active ingredient (azadirachtin) is made from the seeds of the neem tree (Azadiracta indica).
  • Neem extracts have been used for centuries to control insects.
  • LALGUARD AZA is NOT neem oil.
  • LALGUARD AZA can be used for both deciduous and coniferous tree species.
  • LALGUARD AZA is intended for non-food crops use only.
  • In the United States, LALGUARD AZA is registered by the Environmental Protection Agency (EPA) as a biopesticide (Reg. No. 64137-14).
  • LALGUARD AZA is to be applied by professional tree care providers.  A list of certified service providers can be found online by visiting  Follow the “find a service provider” link.
  • Since LALGUARD AZA has a higher concentration of azadirachtin than TreeAzin, less product volume is required per inch of tree diameter. The benefits of a smaller dose include:
    • Significant cost-savings
    • A reduction in the volume of product needed to flow through the tree
  • The new LALGUARD AZA formulation allows the active ingredient (azadirachtin) to translocate evenly and effectively throughout the crown of the tree, while maintaining adequate concentrations to remain effective.
  • Can be used in multiple injection systems.
  • Twelve months shelf life. Does not need to be frozen over winter.
  • The new LALGUARD AZA formulation persists longer in plant tissues than TreeAzin, providing longer seasonal coverage.
  • LALGUARD AZA contains formulants that allow for faster translocation and persistence when injected. These ingredients directly affect the speed and dispersal of azadirachtin inside a tree.
  • LALGUARD AZA is injected at the base of the tree, under the bark, directly into the active sapwood, and moves upwards with the flow of water and nutrients. Its is formulated to inject effectively, translocating rapidly throughout the tree (approx. 48 hrs).
  • LALGUARD AZA can also be diluted and sprayed using a suitable power or pump pressure sprayer or hand held trigger type sprayer that will deliver a fine spray mist to cover all leaf and limb surfaces.
  • LALGUARD AZA controls insect larvae feeding on the tree’s tissues by preventing the insect from producing ecdysone, the ‘molting hormone’, thereby disrupting the molting process, effectively controlling the target insects.
  • LALGUARD AZA has multiple modes of action. For many insect pests, including the emerald ash borer, it will also reduce fecundity, by limiting specific insect hormones.
  • LALGUARD AZA is also an antifeedant.  Once adult insects feed on treated plant material, they reduce their feeding on all plant matter, whether treated or not.  This limits their ability to grow, travel, and reproduce.
  • These multiple modes of action help to reduce the potential for resistance in pest populations.
  • LALGUARD AZA is found throughout the tree at effective levels during the growing season and provides up to two years protection against emerald ash borer.
  • LALGUARD has a much longer shelf life (12 months) compared to TreeAzin
  • LALGUARD has easier storage requirements (no refrigeration required)
  • Improved translocation and persistence within the tree allowing for lower dose rate
  • Much more competitive price point; the lower dose rate reduces the cost significantly
  • Continued two-year efficacy
  • When injected, LALGUARD AZA provides up to two (2) years protection against emerald ash borer.
  • Summer injections at a rate of 6 ml/inch of tree diameter provide effective emerald ash borer control.
  • In the year of treatment:
    • Emerald ash borer larvae feeding on treated tree tissues do not complete development, as LALGUARD AZA disrupts the molting process.
    • Female emerald ash borer beetles that feed on treated tree leaves lay significantly fewer eggs.
    • Eggs laid by emerald ash borer beetles who fed on treated trees are less viable.
  • In the year following treatment:
    • Some emerald ash borer larvae hatched from viable eggs do not complete development
    • The number and length of emerald ash borer galleries are significantly reduced in ash.
  • LALGUARD AZA provides effective control of insect pests that consume tree leaves (e.g. Lymantria dispar dispar, tent caterpillars, leaf miners), needles (budworms, sawflies), cambial tissue (e.g. emerald ash borer), shoots (e.g. white pine weevil) and sucking and piercing insects (e.g. scales, hemlock woolly adelgid).
  • In the United States, LALGUARD AZA (Reg. No. 64137-14) is registered by the Environmental Protection Agency (EPA) for the control of many insects as listed on the label:
    • Coleoptera – beetles
      Elm leaf beetle
      Emerald Ash Borer
      Japanese beetle
    • Coleoptera – weevils
      White pine weevil
      Red elm bark weevil
      Beech leaf mining weevil
    • Lepidoptera – caterpillars
      Spongy moth
      Brown tail moth
      Spruce budworm
      Jack pine budworm
      Tent caterpillars
    • Lepidoptera – leaf miners
      Arborvitae leaf miners
      Horse chestnut leaf miner
    • Hemiptera – adelgids
      Hemlock woolly adelgid
    • Hemiptera – aphids
      Linden aphid
    • Hemiptera – scales
      European elm scale 
      Kermes scale
    • Hymenoptera – sawflies
      Birch leaf miner
  • Research trials are underway testing the effectiveness of LALGUARD AZA against other insect pests.
  • LALGUARD AZA is considered an alternative to conventional insecticides.
  • It can be injected under a tree’s bark, directly into the active sapwood for minimal personal, animal and environmental exposure.
  • It degrades naturally within tree tissues and the environment, allowing leaves of treated trees to be composted for use in gardening within minimal risk.
  • When used as labeled, LALGUARD AZA poses minimal risk to:
    • Applicators, bystanders, and pets
    • Bees, birds, and mammals
    • Soil and aquatic ecosystems
  • According to a 2010 Canadian Forest Service publication, the botanical origin of LALGUARD AZA (azadirachtin), coupled with its low risk toxicological characteristics, makes it suitable for use in urban settings and environmentally sensitive areas.
  • LALGUARD AZA can be sprayed or injected into trees systemically.
  • LALGUARD AZA is injected under a tree’s bark, directly into the active sapwood, and moves upwards with the flow of water and nutrients.
  • For foliar spray applications, apply LALGUARD AZA diluted. Consult the LALGUARD AZA label or contact a technical specialist to confirm foliar spray application directions.
  • To spray LALGUARD AZA, select a suitable power or pump pressure sprayer or a hand held trigger type sprayer that will deliver a fine spray mist to cover all plant target surfaces.
  • LALGUARD AZA is designed for use with the EcoJect System for tree injections or with other manufacturers’ tree injection devices that meet the label and dosage requirements.
  • The EcoJect System is a tree microinjection system for the application of systemic pesticides into high value trees (US Patent 7,114,289).  This system allows for the injection of multiple trees at once using refillable canisters.
  • LALGUARD AZA is to be applied by professional tree care providers.
  • DO NOT DELAY, have your tree assessed by a qualified service provider or tree care provider as soon as possible.
  • Review the searchable listing of licensed pesticide applicators offering LALGUARD AZA treatment services for emerald ash borer and other insect pests.

How do I become a licensed pesticide applicator?

  • If you are a tree care professional or pesticide applicator looking to add LALGUARD AZA treatments to your list of services in the United States, please contact us.
  • For information on pesticide applicator licensing visit the EPA’s website.
  • LALGUARD AZA is designed to be used with the EcoJect System for tree injections, but could be compatible with a similar tree injection system.
  • Contact your technical specialist at BioForest to confirm if LALGUARD AZA is compatible with a different tree injection system.

Currently, LALGUARD AZA is only available in the United States and is currently registered in the following states:

  • Colorado
  • Massachusetts
  • Missouri
  • Wisconsin
Product Information Sheet
Product Information Sheet